The effect of size, morphology and surface properties of mesoporous silica nanoparticles on pharmacokinetic aspects and potential toxicity concerns

Mesoporous silica nanoparticles (MSNs) are considered as suitable delivery vehicles considering their unique characteristics. Various physicochemical characteristics of MSNs govern pharmacokinetic parameters which affect the disposition these in body. Along with advantages MSNs, toxicity entering body is a major concern. factors such particle size, surface charge, route administration, etc. , may organ MSNs. The main target organs involved metabolism and elimination kidney liver well hematopoietic system. In this review, we first introduced properties including drug absorption bio-distribution. Thereafter, discussed mechanisms by occur. regard, effects various on organ-based toxicities molecular have been summarized. At last, emphasized role toxicities, proposed approaches to prevent or at least diminish MSN-related detail.